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Newsletter

Enzyme and substrate measurements in the Gaucher disease mouse model 4L/PS-NA

Feb 2, 2019

QPS Neuropharmacology

QPS Austria is now able to offer Glucocerebrosidase (Gcase) activity as well as Glucosylceramide (GlcCer) and Glucosylsphingosine (GlcSph) measurements in your 4L/PS-NA study animals! These animals express the homozygous GbaV394L/V394L mutation (4L), have a complete prosaposin knockout (PS-) and a homozygous prosaposin transgene (NA) resulting in hypomorphic prosaposin levels. Measurement of GCase activity in brain …

Enzyme and substrate measurements in the Gaucher disease mouse model 4L/PS-NA

Jan 2, 2019

QPS Neuropharmacology

GBA1 deficiency and mutations are related to Gaucher disease, but are also shown to be linked to neurodegenerative events, e.g. in Parkinsons disease. QPS Austria offers the analysis of GCase activity in various in vitro and in vivo models like 1. mouse embryonic fibroblasts (MEFs) of 4L/PS-NA mice and 2. CBE treated D-Line mice, respectively. …

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In Vitro Services

QPS Neuropharmacology provides research services with numerous standardized cell culture systems including transgenic and non-transgenic cell lines, glial cells, primary chicken and rat peripheral and central nervous system neurons of different developmental stages and organotypic brain slices. New models are developed and validated on request.

In Vivo Services

As a leading CRO for CNS drug development, QPS Neuropharmacology is the premier provider for services with transgenic animals. We have more than 20 years of experience in generating, characterizing, and maintaining transgenic disease models and applying them for drug testing projects.

Ex Vivo Services

QPS Neuropharmacology's expertise lies within the field of neurodegenerative diseases. We provide a state of the art research environment (AAALAC certified) for testing and evaluating new potential treatment approaches.

Biobank

QPS Neuropharmacology's well characterized and validated in vivo models are useful tools to push your CNS drug discovery research forward. We are happy to support your research activities with sample material from our biobank composed of various specimen derived from our in-house in vivo models.

animal models

QPS Neuropharmacology is highly experienced in generating, characterizing, and maintaining transgenic disease models and using them for drug testing projects for more than 20 years.

behavioral testing

QPS Neuropharmacology provides a wide range of behavioral tests for various indications. Most tests are evaluated using rater-independent digital animal tracking systems.

histology services

QPS Neuropharmacology offers a full set of histology services ranging from collection of tissue samples to delivering study reports that contain all experimental procedures and their outcome.

biomarkers

QPS Neuropharmacology Department of Translational Medicine offers a selection of molecular biological methods for the investigation of various diseases. The unit supports in vitro and in vivo studies performed at QPS Austria.

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