Neuroinflammation is a growing field of research in the fight against neurodegenerative diseases and other disorders affecting the central nervous system. We have previously shown that NPC1-/- mice exhibit strong inflammation (Santiago-Mujica et al., 2019). To further elucidate inflammation in the brain of NPC1-/- mice, we now evaluated CD45 analysis in the thalamus (A) and …

Neuroinflammation is a growing field of research in the fight against neurodegenerative diseases and other disorders affecting the central nervous system. We have already shown that 4L/PS-NA mice exhibit strong inflammation in visceral organs and cortical brain regions (Schiffer et al., 2020). Since the cerebellum of 4L/PS-NA mice presents with a highly disturbed morphology (Schiffer …

Besides transgenic rodent models QPS Neuropharmacology provides one of the most frequently used animal models for PD utilizing unilateral injection of 6- hydroxydopamine (6-OHDA) into the medial forebrain bundle (MFB) in rats, which results in total denervation of the dopaminergic nigrostriatal pathway. Figure 1: Unilateral injection into the MFB of saline (A, B) or 6-OHDA …

LPS-stimulated organotypic hippocampal slices provide an optimal tool to investigate the impact of developmental compounds on inflammasome activation in vitro. By maintaining the three-dimensional structure and interplay of different cell types of the postnatal brain, this system closely resembles the in vivo situation while offering several advantages for early screenings: take supernatant samples anytime test …

Biomarkers and their use in neurodegenerative disease research delineates a rising area of research and may provide an important link between preclinical disease models and evaluation of disease progression in patients. Neurofilament light chain (NF-L), a neuronal cytoplasmic protein, is increased in a variety of neuronal diseases due to axonal damage. A strong increase of …