To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community with quick delivery and at low cost. QPS Neuropharmacology obtained the right to offer the following MJFF mouse models to its customers and would be happy to perform your study in these models.
| Ninja Column 1 | Ninja Column 2 | Ninja Column 3 | Ninja Column 4 | Ninja Column 5 | Ninja Column 6 |
|---|---|---|---|---|---|
| LRRK1 | LRRK1 KO | Knockout | 16120 | knockout exons 24 throught 29 of Lrrk1 | https://www.jax.org/strain/016120 |
| LRRK1 | LRRK1 KO | Knockout | 22880 | knockout exons 24 throught 29 of Lrrk1, no Pde6b | https://www.jax.org/strain/022880 |
| LRRK1 and LRRK2 | LRRK1/2 double KO | 16122 | knockout exons 24 throught 29 of Lrrk1 and knockout exons 39 throught 40 of Lrrk2 | https://www.jax.org/strain/016122 | |
| LRRK2 | BAC Human LRRK2 wildtype | Knockout | 13725 | BAC transgene expresisng WT LRRK2 enodgenouse promotor | https://www.jax.org/strain/013725 |
| LRRK2 | BAC Human LRRK2 R1441G | Transgenic | 18786 | BAC LRRK2(R1441G) enodenous promotor | https://www.jax.org/strain/018786 |
| LRRK2 | BAC Human LRRK2 G2019S | Transgenic | 18785 | BAC LRRK2 (G2019S) transgene | https://www.jax.org/strain/018785 |
| LRRK2 | LRRK2 KO | Transgenic | 16121 | knockout exons 39 throught 40 of Lrrk2 | https://www.jax.org/strain/016121 |
| LRRK2 | LRRK2 D1994A KI | Knockout | 21830 | D1994A point mutation in Lrrk2 | https://www.jax.org/strain/021830 |
| LRRK2 | LRRK2 T1348N KI | Knockin | 21829 | T1348N point mutation in Lrrk2 | https://www.jax.org/strain/021829 |
| LRRK2 | LRRK2 A2016T KI | Knockin | 21828 | A2016T point mutation in Lrrk2 | https://www.jax.org/strain/021828 |
| SNCA | BAC Human alphasynuclein wildtype | Knockin | 18442 | BAC murine promotor Human WT SNCA | https://www.jax.org/strain/018442 |
| SNCA | mThy-1 Human alpha-synuclein | Transgenic | 16936 | Murine Thy1 promotor, human WT SNCA | https://www.jax.org/strain/016936 |
| SNCA | mThy-1 Human alpha-synuclein | Transgenic | 17682 | Murine Thy1 promotor, human WT SNCA | https://www.jax.org/strain/017682 |
| SNCA | Alpha-synuclein KO | Knockout | 16123 | knockout exons 1 through 4 of murine SNCA | https://www.jax.org/strain/016123 |
| Eif4g1 | Eif4g1 R1207H | Knockin | 24521 | R1207H in exon 24, as well as loxP sites flanking exons 24 to 28. Crebmediated recombination removes exon 24 to 28 resulting in null allele. | https://www.jax.org/strain/024521 |
| Eif4g1 | Eif4g1 KO | Conditional Knockout | 21827 | LoxP sites flanking exons 24 to 28. Creb-mediated recombination removed exon 24 to 28 resulting in null allele. | https://www.jax.org/strain/021827 |
| VPS35 | VPS35 D620N KI | Knockin | 23409 | D620N mutation in exon 15 | https://www.jax.org/strain/023409 |
| VPS35 | VPS35 D620N KIfloxΔneo Vps35 | Conditional Knockout | 21807 | Cre recombinase inducible D620N mutation in exon 15 | https://www.jax.org/strain/021807 |
| GBA | GBA D409V KI | Knockin | 19106 | Gba D427V mutant protein corresponse to D409V | https://www.jax.org/strain/019106 |