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Primary TH Neurons

Primary TH Neurons

The degeneration of midbrain dopaminergic neurons is the hallmark of the pathology of Parkinsons Disease (PD). Dopaminergic neurons represent less than 1% of the total number of neurons in the brain, though regulating such important brain functions as motor control, motivation, and working memory. Primary cultures constitute one of the most relevant models to investigate properties and characteristics of dopaminergic neurons.

QPS Neuropharmacology provides primary dopaminergic TH (tyrosine hydroxylase) positive neurons from the ventral mesencephalon of rats. These cultures can be submitted to various stress agents that mimic PD pathology (MPP+, 6-OHDA) and to neuroprotective compounds in order to stop or slow down neuronal degeneration. A software supported automatic quantification method allows the determination of the following end points such as TH cell numbers, neurite outgrowth or apoptosis. A controlled regeneration or the prevention of degeneration of dopaminergic neurons are promising therapeutic approaches.

TH-2

Figure: Effects of a developmental Compound X on the number of primary rat TH neurons from the ventral mesencephalon.

In Vitro Services

QPS Neuropharmacology provides research services with numerous standardized cell culture systems including transgenic and non-transgenic cell lines, glial cells, primary chicken and rat peripheral and central nervous system neurons of different developmental stages and organotypic brain slices. New models are developed and validated on request.
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In Vivo Services

As a leading CRO for CNS drug development, QPS Neuropharmacology is the premier provider for services with transgenic animals. We have more than 20 years of experience in generating, characterizing, and maintaining transgenic disease models and applying them for drug testing projects.
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Ex Vivo Services

QPS Neuropharmacology's expertise lies within the field of neurodegenerative diseases. We provide a state of the art research environment (AAALAC certified) for testing and evaluating new potential treatment approaches.
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Biobank

QPS Neuropharmacology's well characterized and validated in vivo models are useful tools to push your CNS drug discovery research forward. We are happy to support your research activities with sample material from our biobank composed of various specimen derived from our in-house in vivo models.
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animal models

QPS Neuropharmacology is highly experienced in generating, characterizing, and maintaining transgenic disease models and using them for drug testing projects for more than 20 years.
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behavioral testing

QPS Neuropharmacology provides a wide range of behavioral tests for various indications. Most tests are evaluated using rater-independent digital animal tracking systems.
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histology services

QPS Neuropharmacology offers a full set of histology services ranging from collection of tissue samples to delivering study reports that contain all experimental procedures and their outcome.
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biomarkers

QPS Neuropharmacology Department of Translational Medicine offers a selection of molecular biological methods for the investigation of various diseases. The unit supports in vitro and in vivo studies performed at QPS Austria.
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