We now offer advanced search strategy analysis of data gathered during Morris Water Maze (MWM) test without changes to the established protocol. The MWM has been a widely recognized method to analyze spatial navigation and learning for several decades. This makes it a valuable tool for the evaluation of cognitively impaired rodent models, used to …

Newest results of our R&D team show highly increased total and phosphorylated tau (ptau) levels in transgenic PS19 mice already at early age. This rodent model for tauopathies expresses the T34 isoform and 4 microtubule binding repeats (1N4R) of the tau protein with P301S mutation under the regulatory control of the murine prion promoter (Prnp). …

We are now able to offer longitudinal, repeated in vivo electromyographic measurements in rodent models with motor impairment. These analyses provide sensitive longitudinal readouts about your drug candidates that are unaffected by the environmental or emotional status of your animals. Typical readouts are the Compound Muscle Action Potential (CMAP), Motor Unit Action Potential (MUAP) and …

Reduced GCase activity is a key causative hallmark of Gaucher disease. Monitoring changes in GCase activity at multiple time points from small volumes of whole blood, sampled as dried blood spots (DBS), can give valuable new insights on drug effects. Mutations in the human glucosylceramidase-β (GBA) gene and associated GCase activity are causative for Gaucher …

Repeated MPTP injections into the mouse’ intraperitoneal space result in a Parkinson´s disease brain pathology shown as degeneration of dopaminergic neurons and neuroinflammation. Upon entering the brain, methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) oxidizes into the highly neurotoxic compound 1-methyl-4-phenylpyridinium (MPP+) which is selectively taken up by dopaminergic neurons. Inside neurons, MPP+ disrupts mitochondrial function and causes oxidative stress, …